XI-ZOMES

PROGRAM

 

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Wednesday, 31st August 2022

15:00-17:30 Arrival, check-in
17:30 Michael Naumann
"Welcome"

17:40

 

Session 1

PCI-complexes, structures and mechanisms I

  T1 Brenda Schulman: Structural regulation of and by cullin-RING E3 ligases
  T2 Raymond Deshaies: Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication.
 

Special talk: Director of Magdeburg Museums - Dr. Gabriele Köster

"The glance of Magdeburg"

20:00-23:00

Dinner buffet / get together

 

Thursday, 1st September 2022

6:30-9:00 Breakfast (for hotel guests)

9:00

 

Session 2

PCI-complexes, structures and mechanisms II

 

T4 Elah Pick: Thiol-based redox control of NEDD8 pathways

 

T4 Tom Tsuge: Is CSN involved in pre-mRNA processing? - CSN binding protein complex CF1 is essential for maintaining the diversity at the 3' ends of mRNA.

  T5 Rasmus Hartmann-Petersen: Proteostasis analyzed through deep mutational scanning
  T6 Leos Valasek: eIF3 at the tip of the AUG selection process
11:00:11:30 Coffee break

11:30

 

Session 3

ZOMES and proteostasis I

  T7 Erika Isono: Control of endocytic degradation by deubiquitylating enzymes
  T8 Michal Sharon: Allosteric regulation of the 20S proteasome by the catalytic core regulators (CCRs) family
  T9 Olivier Coux: PA28γ, a proteasome regulator involved in intranuclear dynamics
  T10 Giovanna Serino: COP1 and light signalling regulate the development of flower organs
13:30-15:00 

Light meal / group photo

“Editor-in-chief”-lunch: Prof. Lienhard Schmitz – Biochim Biophys Acta - Mol Cell Res

15:00

 

Session 4

ZOMES and proteostasis II

  T11 Yasushi Saeki: Ubiquitylation-dependent phase separation of the proteasome
  T12 Michael Groll: Targeting the proteasome by bioactive peptides
  T13 Gunnar Dittmar: Analysis of the claudin family places a subset of proteasomes at the tight junction
16:40-17:00 Coffee break

17:00

 

Session 5

Selected three minutes & one question talks

  ST1 Alihamze Fathinajafabadi: Implication of eIF5A2 in the control of protein synthesis during cancer progression
  ST2 Yuan Tian: The COP9 signalosome protects from microglial inflammation and hypoxic neuronal damage
  ST3 Norbert Nass: Expression and function of eukaryotic initiation factors in CEBPA-mutated acute myeloid leukemia
  ST4 Martin Böttcher: CLL-derived extracellular vesicles impair T-cells via multiple immune checkpoint proteins
  ST5 Omar El Bounkari: Effects of mimicking CSN5 activity by MLN4924 on microglia motility in vivo
  ST6 Jiale Du: A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation
  ST7 Ajay Wagh: Elucidating the molecular mechanism of mutant ubiquitin (UBB+1) secretion
  ST8 Kunjan Harit: Ablation of OTUD7B in dendritic cells confers protection against ECM
18:15-23:00 walk through Magdeburg to special evening event at Festung Mark

 

Friday, 2nd September 2022

6:30-9:00 Breakfast (for hotel guests)

9:00

 

Session 6

PCI-complexes, structures and mechanisms III

  T14 Xing Wang Deng: Structural insight into UV-B-activated UVR8 bound to COP1
  T15 Qi Xie: Fine tuning between different ERAD complex in plant growth and environment interaction
  T16 Ning Wei: The role of the COP9 signalosome (CSN) in FBP recruitment to the SCF complex in Arabidopsis Thaliana
 

T17 Feng Rao: Glucose-induced CSN-CRL4 to CRL4-COP1 transition promotes diabetes and cancer

11:00-11:30 Coffee break

11:30

 

Session 7

PCI-complexes, structures and mechanisms IV

 

T18 Michael Naumann: Role of CSN–associated DUBs in apoptotic cell death

  T19 Dimitris Xirodimas: NEDD8 and the cytoplasmic Protein Quality Control System
  T20 Gerhard Braus: Cellular assembly of the native fungal COP9 signalosome 
  T21 Paula da Fonseca: Exploring the intricate regulation of the human 26S proteasome
13:30-15:00 Light meal

15:00

 

Session 8

ZOMES and proteostasis III

  T22 Michael Glickman: Disassembly of 26S proteasomes and potential roles of liberated free 20S proteasomes
  T23 Dieter A. Wolf: mRNA selective modules define the multifunctionality of eIF3 in mRNA translation
  T24 Yaser Hashem: mRNA translation initiation alteration in colorectal cancer
  T25 Arno Alpi: Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation
17:00-17:30 Coffee break

17:30

 

Session 9

ZOMES and cell physiology I

  T26 Ayala Shiber: Identification and characterization of novel quality control factors acting on the ribosome
  T27 Kay Hofmann: Disentangling Nedd8- and ubiquitin-modification sites by modifier-selective C-terminal clippases
  T28 Dawadschargal Dubiel: Is COP9 signalosome (CSN) a substrate of autophagy? 
19:30-21:00 Dinner buffet

21:00

 

Session 10

Selected three minutes & one question talks

  ST9 Shahar Levi: Dissecting the properties of the UBL domain of proteasome associated DUBs
  ST10 Indrajit Sahu: Alpha2 subunit of proteasome core-particle regulates substrate proteolysis
  ST11 Eric Schulze-Niemand: Simulated association of CSN effector proteins
  ST12 Soha Issa: Yuh1 is a redox responsive enzyme that determines cullin NEDDylation status
  ST13 Shany Greenstein: Understanding the turnover of the truncated form of mutant ubiquitin, UBB+1
  ST14 Juanjuan Chen: Ablation of neuroplastin expression in GABAergic interneurons induces retrograde amnesia of associative memories
  ST15 Phatcharida Jantaree: USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection
21:30 Get-together

 

Saturday, 3rd September 2022

6:30-8:00 Breakfast (for hotel guests)

8:30

 

Session 11

ZOMES and cell physiology II

  T29 Jürgen Bernhagen: Protective Role of the COP9 Signalosome in Atherogenic Inflammation
  T30 Wolfgang Dubiel: COP9 signalosome variants, CSNCSN7A and CSNCSN7B, are vital for DNA repair and adipogenesis
  T31 Jun-Ya Kato: Tumor-specific functions of the fifth component of the COP9 signalosome complex (CSN5)
  T32 Johannes Haybaeck: The contribution of translation initiation factors to carcinogenesis
11:00-11:30 Farewell/conclusion; presentation of next ZOMES XII location

 

 

Last Modification: 22.08.2022 - Contact Person: XI-ZOMES