PROGRAM
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Wednesday, 31st August 2022 |
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| 15:00-17:30 | Arrival, check-in |
| 17:30 | Michael Naumann "Welcome" |
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17:40
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Session 1 PCI-complexes, structures and mechanisms I |
| T1 Brenda Schulman: Structural regulation of and by cullin-RING E3 ligases | |
| T2 Raymond Deshaies: Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication. |
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Special talk: Director of Magdeburg Museums - Dr. Gabriele Köster "The glance of Magdeburg" |
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20:00-23:00 |
Dinner buffet / get together |
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Thursday, 1st September 2022 |
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| 6:30-9:00 | Breakfast (for hotel guests) |
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9:00
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Session 2 PCI-complexes, structures and mechanisms II |
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T4 Elah Pick: Thiol-based redox control of NEDD8 pathways |
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T4 Tom Tsuge: Is CSN involved in pre-mRNA processing? - CSN binding protein complex CF1 is essential for maintaining the diversity at the 3' ends of mRNA. |
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| T5 Rasmus Hartmann-Petersen: Proteostasis analyzed through deep mutational scanning | |
| T6 Leos Valasek: eIF3 at the tip of the AUG selection process | |
| 11:00:11:30 | Coffee break |
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11:30
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Session 3 ZOMES and proteostasis I |
| T7 Erika Isono: Control of endocytic degradation by deubiquitylating enzymes | |
| T8 Michal Sharon: Allosteric regulation of the 20S proteasome by the catalytic core regulators (CCRs) family | |
| T9 Olivier Coux: PA28γ, a proteasome regulator involved in intranuclear dynamics | |
| T10 Giovanna Serino: COP1 and light signalling regulate the development of flower organs | |
| 13:30-15:00 |
Light meal / group photo “Editor-in-chief”-lunch: Prof. Lienhard Schmitz – Biochim Biophys Acta - Mol Cell Res |
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15:00
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Session 4 ZOMES and proteostasis II |
| T11 Yasushi Saeki: Ubiquitylation-dependent phase separation of the proteasome | |
| T12 Michael Groll: Targeting the proteasome by bioactive peptides | |
| T13 Gunnar Dittmar: Analysis of the claudin family places a subset of proteasomes at the tight junction |
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| 16:40-17:00 | Coffee break |
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17:00
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Session 5 Selected three minutes & one question talks |
| ST1 Alihamze Fathinajafabadi: Implication of eIF5A2 in the control of protein synthesis during cancer progression | |
| ST2 Yuan Tian: The COP9 signalosome protects from microglial inflammation and hypoxic neuronal damage | |
| ST3 Norbert Nass: Expression and function of eukaryotic initiation factors in CEBPA-mutated acute myeloid leukemia | |
| ST4 Martin Böttcher: CLL-derived extracellular vesicles impair T-cells via multiple immune checkpoint proteins | |
| ST5 Omar El Bounkari: Effects of mimicking CSN5 activity by MLN4924 on microglia motility in vivo | |
| ST6 Jiale Du: A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation | |
| ST7 Ajay Wagh: Elucidating the molecular mechanism of mutant ubiquitin (UBB+1) secretion | |
| ST8 Kunjan Harit: Ablation of OTUD7B in dendritic cells confers protection against ECM | |
| 18:15-23:00 | walk through Magdeburg to special evening event at Festung Mark |
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Friday, 2nd September 2022 |
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| 6:30-9:00 | Breakfast (for hotel guests) |
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9:00
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Session 6 PCI-complexes, structures and mechanisms III |
| T14 Xing Wang Deng: Structural insight into UV-B-activated UVR8 bound to COP1 | |
| T15 Qi Xie: Fine tuning between different ERAD complex in plant growth and environment interaction | |
| T16 Ning Wei: The role of the COP9 signalosome (CSN) in FBP recruitment to the SCF complex in Arabidopsis Thaliana | |
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T17 Feng Rao: Glucose-induced CSN-CRL4 to CRL4-COP1 transition promotes diabetes and cancer |
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| 11:00-11:30 | Coffee break |
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11:30
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Session 7 PCI-complexes, structures and mechanisms IV |
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T18 Michael Naumann: Role of CSN–associated DUBs in apoptotic cell death |
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| T19 Dimitris Xirodimas: NEDD8 and the cytoplasmic Protein Quality Control System | |
| T20 Gerhard Braus: Cellular assembly of the native fungal COP9 signalosome | |
| T21 Paula da Fonseca: Exploring the intricate regulation of the human 26S proteasome | |
| 13:30-15:00 | Light meal |
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15:00
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Session 8 ZOMES and proteostasis III |
| T22 Michael Glickman: Disassembly of 26S proteasomes and potential roles of liberated free 20S proteasomes | |
| T23 Dieter A. Wolf: mRNA selective modules define the multifunctionality of eIF3 in mRNA translation | |
| T24 Yaser Hashem: mRNA translation initiation alteration in colorectal cancer |
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| T25 Arno Alpi: Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation | |
| 17:00-17:30 | Coffee break |
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17:30
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Session 9 ZOMES and cell physiology I |
| T26 Ayala Shiber: Identification and characterization of novel quality control factors acting on the ribosome | |
| T27 Kay Hofmann: Disentangling Nedd8- and ubiquitin-modification sites by modifier-selective C-terminal clippases | |
| T28 Dawadschargal Dubiel: Is COP9 signalosome (CSN) a substrate of autophagy? | |
| 19:30-21:00 | Dinner buffet |
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21:00
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Session 10 Selected three minutes & one question talks |
| ST9 Shahar Levi: Dissecting the properties of the UBL domain of proteasome associated DUBs | |
| ST10 Indrajit Sahu: Alpha2 subunit of proteasome core-particle regulates substrate proteolysis | |
| ST11 Eric Schulze-Niemand: Simulated association of CSN effector proteins | |
| ST12 Soha Issa: Yuh1 is a redox responsive enzyme that determines cullin NEDDylation status | |
| ST13 Shany Greenstein: Understanding the turnover of the truncated form of mutant ubiquitin, UBB+1 | |
| ST14 Juanjuan Chen: Ablation of neuroplastin expression in GABAergic interneurons induces retrograde amnesia of associative memories | |
| ST15 Phatcharida Jantaree: USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection | |
| 21:30 | Get-together |
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Saturday, 3rd September 2022 |
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| 6:30-8:00 | Breakfast (for hotel guests) |
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8:30
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Session 11 ZOMES and cell physiology II |
| T29 Jürgen Bernhagen: Protective Role of the COP9 Signalosome in Atherogenic Inflammation | |
| T30 Wolfgang Dubiel: COP9 signalosome variants, CSNCSN7A and CSNCSN7B, are vital for DNA repair and adipogenesis | |
| T31 Jun-Ya Kato: Tumor-specific functions of the fifth component of the COP9 signalosome complex (CSN5) | |
| T32 Johannes Haybaeck: The contribution of translation initiation factors to carcinogenesis | |
| 11:00-11:30 | Farewell/conclusion; presentation of next ZOMES XII location |
